Comparison of the Degradability of Hyaluronic Acid by Ovine and Recombinant Human Hyaluronidase
This study demonstrates that 300 U of hyaluronidase is sufficient to degrade 0.2 mL of the most resistant hyaluronic acid fillers within 1 hour. Importantly, a minimum dilution of 3:1 should be used to provide adequate fluid for dissolving filler. Ovine HYAL appears to be just as effective as recombinant HYAL in terms of dissolving product.
Authors
- Andreas Nikolis (ORCID: https://orcid.org/0000-0002-9056-4998)
- Andrei I. Metelitsa (ORCID: https://orcid.org/0000-0001-5482-680X)
- Tyler Safran (ORCID: https://orcid.org/0000-0002-0795-3109)
- Julie A. Woodward
- Roy Khalaf (ORCID: https://orcid.org/0009-0008-7807-7557)
Institutions
- University of Calgary (CA)
- Duke University (US)
- McGill University Health Centre (CA)
- Dawson College (CA)
- Canadian Institute of Mining, Metallurgy and Petroleum (CA)
- McGill University (CA)
Publication Details
- Journal
- Aesthetic Surgery Journal
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1093/asj/sjaf127
- Citations
- 1
- Primary Topic
- Facial Rejuvenation and Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.00