Optimized synthesis of aroyl-<i>S,N</i>-ketene acetals by omission of solubilizing alcohol cosolvents.
Aroyl-<i>S</i>,<i>N</i>-ketene acetals are obtained by condensation of aroyl chlorides and 2-methyl-<i>N</i>-benzylbenzothiazolium salts in 1,4-dioxane at room temperature in short reaction time in 20-99% yield. This protocol represents a considerable improvement over the standard synthesis in 1,4-dioxane/ethanol mixtures at elevated temperatures.
Authors
- Julius Krenzer (ORCID: https://orcid.org/0000-0002-7901-0214)
- Thomas J. J. Müller (ORCID: https://orcid.org/0000-0001-9809-724X)
Institutions
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3762/bjoc.21.97
- Primary Topic
- Organic Chemistry Cycloaddition Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00