Mitotherapy attenuates sepsis-induced brain injury in rats subjected to cecal ligation and puncture: Role of SIRT-1/PGC-1α network.
Mitotherapy mitigated sepsis-induced brain injury by improving mitochondrial function, biogenesis, and dynamics within the SIRT-1/PGC-1α network and concurrently suppressing inflammation. Repetitive injections exhibited enhanced potency, suggesting a novel avenue for managing sepsis-associated brain dysfunction.
Authors
- Reza Badalzadeh (ORCID: https://orcid.org/0000-0002-8092-7820)
- Soleyman Bafadam (ORCID: https://orcid.org/0000-0002-6644-5219)
- Behnaz Mokhtari (ORCID: https://orcid.org/0000-0002-3355-9869)
- Ata Mahmoodpoor (ORCID: https://orcid.org/0000-0002-4361-6230)
- Alireza Alihemmati (ORCID: https://orcid.org/0000-0002-2929-006X)
- Solmaz Boraghi
Institutions
- Tabriz University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.84848.18363
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tabriz University of Medical Sciences
- University of Tabriz