Photodynamic therapy of basal cell carcinoma of the face H-zone

This article reviews clinical experience in treating skin neoplasms using photodynamic therapy with combined ultrasound and fluorescence diag- nostics for neoplasms in the nose, lateral face, and adjacent areas. Injectable forms of chlorine-type drugs were used as photosensitizers – photodi- tazine or photoran at a dose of 0.7 to 2.5 mg per kilogram of patient body weight. The drug was administered intravenously for 30 minutes 2.5-3.0 hours before tumor irradiation. Of 107 observations over a 9-month observation period, one case of marginal tumor recurrence in the treatment area was detected. Thus, the recurrence rate was 0.93%. The results show that three-dimensional tumor visualization for the H-zone with complex noninvasive diagnostics allows achieving high efficiency in photodynamic therapy of non-melanoma tumors of the above anatomical localizations.