E-cigarettes in people with substance use disorder

People with substance use disorder (SUD) have a high prevalence of cigarette smoking.1 Clinical trials of smoking cessation interventions with efficacy in the overall population of people who smoke have had little success in people with SUD, in part due to methodological limitations.2 Innovative and effective tobacco cessation treatments are urgently needed for this group. Nicotine-containing electronic cigarettes (e-cigarettes) are non-combustible nicotine products with substantial evidence of smoking cessation efficacy among people who smoke cigarettes,3 but few randomised trials have tested e-cigarettes for people with SUD.