A Novel Retinal Nerve Fiber Layer Biomarker of Amyotrophic Lateral Sclerosis (ALS) Identified Using Longitudinal in vivo Ocular Imaging
Our findings demonstrate distinct inner retinal nerve fiber layer pathology, detected using cSLO coupled with OCT, which worsens over time. These findings support the potential of retinal imaging as a translationally relevant, non-invasive biomarker for ALS diagnosis or disease monitoring in humans.
Authors
- Farbod Khorrami (ORCID: https://orcid.org/0000-0001-5297-4913)
- Yeni Yucel (ORCID: https://orcid.org/0000-0002-5287-1575)
- Neeru Gupta (ORCID: https://orcid.org/0000-0001-8141-7710)
- Xun Zhou (ORCID: https://orcid.org/0009-0008-0408-6442)
- You Liang
Institutions
- St. Michael's Hospital (CA)
- University of British Columbia (CA)
- University of Toronto (CA)
- Metropolitan University (RS)
- Toronto Metropolitan University (CA)
Publication Details
- Journal
- Eye and Brain
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/eb.s516163
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ALS Society of Canada
- Canadian Institutes of Health Research