Cell-type-specific responses to single-pulse electrical stimulation of the human brain
This study bridges a gap in the neuromodulation field by examining the single-unit, cell-type-specific FR responses to direct electrical stimulation of the human brain. We show that low-frequency, single-pulse stimulation broadly elicits suppression, but parameters, such as distance, can have diverse effects on FR. This work informs the neuronal basis of stimulation-evoked potential generation, cell-type-specific responses to stimulation, and has clinical implications for the diagnosis and treatment of drug-resistant epilepsy.
Authors
- Tyler S. Davis (ORCID: https://orcid.org/0000-0001-8823-6189)
- Elliot H. Smith (ORCID: https://orcid.org/0000-0003-4323-4643)
- Ben Shofty (ORCID: https://orcid.org/0000-0002-2949-4740)
- Bornali Kundu (ORCID: https://orcid.org/0000-0002-3613-3695)
- Catherine A. Schevon (ORCID: https://orcid.org/0000-0002-4485-7933)
- Rhiannon L Cowan
- Shervin Rahimpour (ORCID: https://orcid.org/0000-0003-2718-181X)
- John D. Rolston (ORCID: https://orcid.org/0000-0002-8843-5468)
- Edward M. Merricks (ORCID: https://orcid.org/0000-0001-8172-3152)
Institutions
- University of Utah (US)
- Massachusetts General Hospital (US)
- University of Missouri (US)
- Columbia University (US)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.brs.2025.06.017
- Citations
- 2
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- University of Utah