Quantitative whole-body dynamic planar scintigraphy in mice with 99mTc and 161Tb
Using a common radionuclide and one of emerging radiotherapeutic interest, whole-body injected activity and organ-specific ROI values obtained by planar scintigraphy strongly correlated to the true injected activity and values obtained by SPECT following sensitivity-based corrections. The addition of quantitative dynamic planar scintigraphy into the preclinical workflow followed by SPECT imaging adds value to pharmacokinetic and dosimetry assessments of novel gamma-emitting radiopharmaceuticals in imaging and therapeutic applications.
Authors
- Stephen J. Archibald (ORCID: https://orcid.org/0000-0001-7581-8817)
- Isaline Renard (ORCID: https://orcid.org/0000-0003-4121-143X)
- Paul J. Lusby (ORCID: https://orcid.org/0000-0001-8418-5687)
- Juozas Domarkas
- Isis A. Middleton
- John D. Wright
- Émer M Foyle
Institutions
- St Thomas' Hospital (GB)
- Hull York Medical School (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s40658-025-00775-y
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Hull
- Directorate for Biological Sciences
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council