Staphylococcus aureus Strains With a Negative Coagulase Tube Test are Associated With Staphylocoagulase Genotypes

The <i>S. aureus</i> lineages may be negative in the coagulase tube test, especially ST15 and ST3911 (from staphylocoagulase genotype X). Our analysis suggests that the observed negativity in the coagulase tube test is due to the inability of particular coagulase types to coagulate the substrate provided in the commercial test. This has implications for using the tube test in differentiating <i>Staphylococcus</i> <i>aureus</i> isolates from other species. The Illumina genome sequencing read-set for each isolate was submitted to the National Center for Biotechnology Information (NCBI) under the accession number PRJNA611667.