Aldo-keto Reductase 1B10 (AKR1B10) Suppresses Sensitivity of Ferroptosis in TNBC by Activating the AKT/GSK3β/Nrf2/GPX4 Axis
AKR1B10 appears to be an important mechanism protecting MDA-MB-231 cells from ferroptosis, possibly through the AKT Ser473/GSK3β Ser9/NRF2/GPX4 pathway. AKR1B10 may be a key factor underlying the therapeutic effect of RSL3 under different exogenous fatty acid microenvironments.
Authors
- Xiaosha Wen (ORCID: https://orcid.org/0000-0002-7873-3541)
- Dixian Luo (ORCID: https://orcid.org/0000-0001-6155-8137)
- Shanli Wu
- Yi Lin
- Jing Wang (ORCID: https://orcid.org/0000-0002-5398-0802)
- Quan Liu (ORCID: https://orcid.org/0000-0001-9994-3743)
- Shenglong Wang (ORCID: https://orcid.org/0000-0001-8269-0436)
- Gun Yang
Institutions
- Shenzhen University (CN)
- ShenZhen People’s Hospital (CN)
- Ningxia Medical University (CN)
- Shenzhen Luohu People's Hospital (CN)
- Southern Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-06-27
- DOI
- https://doi.org/10.31083/fbl36615
- Citations
- 5
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 5.76
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province