Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate
These findings indicate that orally administered TDI is mutagenic in mice, supporting its classification as a mutagenic carcinogen.
Authors
- Masakatsu Natsume
- Katsuyoshi Horibata (ORCID: https://orcid.org/0000-0002-0866-5504)
- Kei‐ichi Sugiyama
- Takaaki Umano
- Kenichi Masumura (ORCID: https://orcid.org/0000-0002-7907-164X)
- Mariko Matsumoto (ORCID: https://orcid.org/0000-0002-4640-0574)
- Takako Iso
- Yasumasa Murata
Institutions
- Shizuoka Sangyo University (JP)
- Iwata City Hospital (JP)
- National Institute of Health Sciences (JP)
Publication Details
- Journal
- Genes and Environment
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s41021-025-00335-x
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Health, Labour and Welfare