[68Ga]Ga-interleukin-2 for imaging activated T-lymphocytes: biochemical characterization and phase I study in normal subjects
We developed an efficient lyophilized kit of THP-desIL2 for <sup>68</sup>Ga-labelling at room temperature in GMP conditions, obtaining excellent in vitro and in vivo results. [<sup>68</sup>Ga]Ga-THP-desIL2 PET/CT studies in humans showed favorable dosimetry and safety, thus highlighting its potential for a wide range of clinical applications, particularly in immune-mediated diseases and cancer.
Authors
- Chiara Lauri (ORCID: https://orcid.org/0000-0002-0314-5059)
- Giancarlo Morelli (ORCID: https://orcid.org/0000-0002-5791-3690)
- Giuseppe Campagna (ORCID: https://orcid.org/0000-0002-1884-9171)
- Valeria Bentivoglio (ORCID: https://orcid.org/0000-0003-4369-2281)
- Michela Varani (ORCID: https://orcid.org/0000-0002-7766-9031)
- Antonella Accardo (ORCID: https://orcid.org/0000-0002-7899-2359)
- Filippo Galli (ORCID: https://orcid.org/0000-0002-3439-6010)
- Alberto Signore (ORCID: https://orcid.org/0000-0001-8923-648X)
Institutions
- CTO Andrea Alesini (IT)
- Azienda Ospedaliera Sant'Andrea (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1007/s00259-025-07430-9
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09