Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin
This is the first report showing that allergen-specific CLA<sup>+</sup> T-cell-mediated IL-22 <i>in vitro</i> response functionally distinguish moderate-to-severe adult AD patients with specific clinical features and activated IL-22 pathway in their lesional skin, paving the way for the selection of patients that may benefit from IL-22-directed therapies.
Authors
- Lídia Sans‐de San Nicolàs (ORCID: https://orcid.org/0000-0002-2828-2842)
- Marta Ferrán (ORCID: https://orcid.org/0000-0003-1198-0641)
- Marta Bertolín‐Colilla (ORCID: https://orcid.org/0000-0002-2514-3230)
- Laia Curto‐Barredo (ORCID: https://orcid.org/0000-0002-7387-4257)
- Irene García‐Jiménez (ORCID: https://orcid.org/0000-0002-1769-354X)
- Tali Czarnowicki (ORCID: https://orcid.org/0000-0002-1157-5227)
- Montserrat Bonfill‐Ortí (ORCID: https://orcid.org/0000-0002-3183-7538)
- Ramón M. Pujol
- Anna Ryzhkova (ORCID: https://orcid.org/0000-0002-7862-7992)
- Luis F. Santamaria‐Babí (ORCID: https://orcid.org/0000-0002-1674-6654)
- Ignasi Figueras‐Nart (ORCID: https://orcid.org/0000-0001-9341-5923)
- Sandra Díez-Ribas (ORCID: https://orcid.org/0009-0007-2485-099X)
- Ana Vivancos-Melenchón
Institutions
- University of Miami (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1599892
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitat de Barcelona
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III
- European Regional Development Fund