Biodistribution of free Francium-221 and Bismuth-213 in Tumour-bearing SCID mice after successful development of Actinium-225/Francium-221 radionuclide generator Set-up
We present an unprecedented concept utilizing LN2 resin in <sup>225</sup>Ac/<sup>221</sup>Fr generator applications. Successfully eluted and injected <sup>221</sup>Fr fractions showed strong accumulation of <sup>221</sup>Fr and <sup>213</sup>Bi in key organs. Our data provide preliminary evidence of the potential contribution of recoiled progeny radionuclides to side-effects in non-targeted organs.
Authors
- Harun Taş (ORCID: https://orcid.org/0000-0002-1586-5360)
- Frans V. Suurs
- Steffen Happel (ORCID: https://orcid.org/0000-0003-3567-9415)
- Christoph Schatz (ORCID: https://orcid.org/0000-0001-8017-3400)
- Yvonne Remde
- Martina Benešová-Schäfer (ORCID: https://orcid.org/0000-0002-8926-5376)
- Urs B. Hagemann (ORCID: https://orcid.org/0009-0003-6509-0844)
- Balázs G. Madas (ORCID: https://orcid.org/0000-0002-0698-4982)
- Martin Schäfer (ORCID: https://orcid.org/0000-0001-6487-3634)
- Sabine Zitzmann-Kolbe (ORCID: https://orcid.org/0000-0002-1476-6299)
- Ingrid Moen (ORCID: https://orcid.org/0000-0001-9814-9644)
- László Mázik
Institutions
- Eötvös Loránd University (HU)
- Bayer (Norway) (NO)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- ITEMS International (FR)
- HUN-REN Centre for Energy Research (HU)
- Bayer (Germany) (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1007/s00259-025-07427-4
- Citations
- 9
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 12.24
Funders
- Bayer