PROSPECTS FOR ASSESSING BARORECEPTIVE REFLEX REGULATION SYSTEMS IN PATIENTS WITH ARTERIAL HYPERTENSION

Introduction. Analysis of the baroreceptive reflex (BRR) can be considered as an objective method for as-sessing transient states underlying the formation of arterial hypertension (AH). Aim. To evaluate the mechanisms and options for regulating the baroreceptive reflex in groups of conditionally healthy individuals and patients with arterial hypertension. Material and methods. The examination was performed in two groups: group 1 – conditionally healthy indi-viduals (38 people), average age 19 ± 0.06 years, group 2 – patients with the main diagnosis of arterial hyper-tension (23 people), average age 65 ± 1.7 years. When performing the clinoorthostatic test, the subjects' car-diointervalogram was recorded and heart rate variability (HRV) indices were analyzed. Results. In group 2, a significant increase in the HF and LF indices in the supine position is determined, which allows us to assess it as a state of resting load. In this group of subjects, a change in body position to a greater extent reveals changes in the HF index, which determines the depression of vagotropic effects. The hysteresis loop, showing the dynamics of the dependence of the LF and HF indices relative to each other under the conditions of the clinoorthostatic test, characterizes the initially weak regulatory potential of the HRV (minimization of the function). Analysis of the hysteresis loop allows us to determine the Set point, which re-flects two extreme manifestations (norm and pathology) of the vegetative mechanisms of the BRR regulation of arterial pressure. Conclusion. It has been established that the clinoorthostatic test in cardiac patients reveals the minimization of the functions of the HRV regulation systems, mainly due to the depression of the vagotropic effect. Deter-mination of the Set points allows us to evaluate the components of the pathogenesis of arterial hypertension in extreme and transitional states. The use of the clinoorthostatic test contributes to the “training” of the barore-ceptive reflex and optimization of the functioning of the autonomic nervous system, which is advisable to use in clinical practice.