Repurposing piroxicam enhances the antineoplastic effects of docetaxel and enzalutamide in prostate cancer cells using 2D and 3D in vitro culture models
Importantly, PXM treatment in combination with Doc or Enz resulted in more pronounced antineoplastic effects compared to single-drug exposure. Our work suggests PXM as a potential adjunctive therapy to enhance the efficacy of conventional treatments in PCa patients.
Authors
- Georges Daoud (ORCID: https://orcid.org/0000-0001-8043-3882)
- Amani Yehya (ORCID: https://orcid.org/0009-0000-5544-7318)
- Wassim G. Abou-Kheir (ORCID: https://orcid.org/0000-0001-9719-9324)
- Yen‐Nien Liu (ORCID: https://orcid.org/0000-0002-3102-8482)
- Fatima Ghamlouche
- Sana Hachem
- Zahraa Salhab
- R. Karami
Institutions
- Taipei Medical University (TW)
- American University of Beirut (LB)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.3389/fcell.2025.1551010
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American University of Beirut