Tributyl phosphate as a type of environmental endocrine disruptor associated with liver fibrosis: insights from NHANES and in vitro validation
Our findings establish TBP as a novel environmental determinant positively correlated with liver fibrosis in U.S. adults. The profibrotic effects appear mediated through transcriptional activation of extracellular matrix remodeling genes, particularly via MMP9 pathway modulation.
Authors
- Huibin Jiang
- Yawen Huang (ORCID: https://orcid.org/0000-0002-1488-9555)
- Liwei Yang (ORCID: https://orcid.org/0000-0001-9655-5534)
- Liting Zhou (ORCID: https://orcid.org/0009-0007-3316-7383)
- Aipeng Ju
- Jiaming Ye (ORCID: https://orcid.org/0000-0003-0578-3617)
- Qi Wen
Institutions
- Jilin University (CN)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.3389/ftox.2025.1623830
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71