CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model
In the <i>E. multilocularis</i> infection mouse model, excretory/secretory products from metacestode vesicles upregulated CD155 expression in hepatocytes, contributing to an immunosuppressive microenvironment and T-cell exhaustion. Targeting CD155 reverses this immunosuppression and mitigates hepatic pathology, highlighting CD155 as a promising therapeutic target for AE.
Authors
- Tuerganaili Aji (ORCID: https://orcid.org/0000-0001-6737-8874)
- Tao Sun (ORCID: https://orcid.org/0000-0002-2800-0921)
- Ning Yang (ORCID: https://orcid.org/0000-0002-0767-6594)
- Jin Chu (ORCID: https://orcid.org/0000-0003-4606-6585)
- Xiaojuan Bi (ORCID: https://orcid.org/0000-0002-8287-1138)
- Junlong Xue
- Hui Liu
- Liang Li (ORCID: https://orcid.org/0000-0003-0745-2571)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-8179-138X)
- Renyong Lin (ORCID: https://orcid.org/0000-0001-8073-2495)
- Guodong Lü (ORCID: https://orcid.org/0009-0004-8833-5071)
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.3389/fmicb.2025.1624387
- Citations
- 2
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Natural Science Foundation of Xinjiang Province
- National Natural Science Foundation of China