Lurasidone induces developmental toxicity and behavioral impairments in zebrafish embryos
These findings demonstrate lurasidone's potential to disrupt neurodevelopment, suggesting perturbations in excitatory/inhibitory neurotransmitter balance and critical cellular pathways. The results highlight neurodevelopmental risks during sensitive periods, underscoring the need for further safety assessment in vulnerable populations (e.g., pregnant women, young patients).
Authors
- Wentian Li (ORCID: https://orcid.org/0000-0003-1155-110X)
- Yuqing Huang (ORCID: https://orcid.org/0000-0002-5617-7548)
- Xiao Han (ORCID: https://orcid.org/0000-0001-9262-7254)
- Fang Wang (ORCID: https://orcid.org/0000-0003-3669-3948)
- L. Zhu (ORCID: https://orcid.org/0000-0003-0682-6287)
- Yufeng Zhang (ORCID: https://orcid.org/0000-0002-5925-9389)
- Huihui Gong (ORCID: https://orcid.org/0000-0002-1638-9810)
- Qianqian Cheng (ORCID: https://orcid.org/0000-0002-3935-5023)
Institutions
- China University of Geosciences (CN)
- Shanghai East Hospital (CN)
- Hubei Normal University (CN)
- Wuhan Sports University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-07-01
- DOI
- https://doi.org/10.3389/fpsyt.2025.1581524
- Citations
- 1
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China