CXC Chemokines and Diabetic Kidney Disease: Reflections and Prospects

糖尿病肾脏病(Diabetic kidney disease, DKD)作为糖尿病微血管疾病(Diabetic microvascular disease, DMiVD)的常见临床表现类型，其全球发病率逐年攀升，目前已成为影响全球健康的问题之一。趋化因子是具有调控细胞活动、炎症反应和促进细胞迁移等功能的小分子蛋白。近年研究表明，作为趋化因子家族的重要亚型，CXC类趋化因子通过调控炎性反应和纤维化进程在DKD发生发展中发挥关键作用。深入解析其作用机制可为DKD的早期诊断和靶向治疗提供新策略。Diabetic kidney disease (DKD), as a common clinical manifestation of diabetic microvascular complications (DMiVD), has seen a steadily increasing global incidence and has become one of the significant global health concerns. Chemokines are small molecular proteins that regulate cellular activities, inflammatory responses, and promote cell migration. Recent studies have shown that CXC chemokines, a critical subtype within the chemokine family, play a pivotal role in the pathogenesis and progression of DKD by modulating inflammatory reactions and fibrotic processes. Elucidating their underlying mechanisms may provide novel strategies for early diagnosis and targeted therapy of DKD.