Interplay of PNPLA3 and TM6SF2 variants in modulating the risk of hepatocellular carcinoma among Egyptian hepatitis C patients
The PNPLA3 (rs738409) polymorphism is a significant risk factor for HCC in Egyptian patients with chronic HCV, with the G allele notably increasing the risk. In contrast, TM6SF2 (rs58542926) polymorphisms did not show a significant association with HCC risk in this population. These findings highlight the potential for genetic screening to identify HCV patients at elevated risk for HCC.
Authors
- Marwa Tahoon
- Inas Moaz (ORCID: https://orcid.org/0000-0002-1874-0539)
- Fatma O. Khalil (ORCID: https://orcid.org/0000-0002-3157-5232)
- Samiha A M El-Mahdy
- Samar Ghanem
- Hossam A. Galbt
- Ahmed Salah Abdelgawad Elbauomy
Institutions
- Menoufia University (EG)
Publication Details
- Journal
- Clinical and Experimental Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5114/ceh.2025.151811
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00