Overexpression of KRAS enhanced the stemness of esophageal cancer cells inhibited by overexpression of circ0043898
Overexpression of circ0043898 reduced CSCs markers and the number of stem cell spheroidization. However, the overexpression of KRAS attenuated the inhibition effect of overexpressed circ0043898 on CSCs marker and the number of stem cell spheroidization. These findings identify a potential therapeutic target for the EC.
Authors
- Xinming Xiong (ORCID: https://orcid.org/0000-0002-7595-4103)
- Wei Wang (ORCID: https://orcid.org/0000-0002-9861-5577)
- Yuanlin Song (ORCID: https://orcid.org/0000-0002-9826-4383)
- Shiqiang Liu (ORCID: https://orcid.org/0000-0001-6468-7751)
- Xin Yang (ORCID: https://orcid.org/0000-0002-5217-0795)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12885-025-14358-8
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province