Sildenafil blunts cholestasis-associated cholemic nephropathy in a rat model of bile duct ligation
The data obtained from this study revealed that sildenafil could significantly protect against renal damage in cholestasis. The effect of sildenafil on oxidative stress and the inflammatory response plays an essential role in its nephroprotective mechanisms.
Authors
- Forouzan Khodaei (ORCID: https://orcid.org/0000-0001-5950-4930)
- Omid Farshad (ORCID: https://orcid.org/0000-0002-0580-8928)
- Tahereh Golzar
- Heresh Rezaei
- Akram Jamshidzadeh (ORCID: https://orcid.org/0000-0003-4461-7291)
- Hossein Niknahad (ORCID: https://orcid.org/0000-0001-6211-5936)
- S Ghaem Maghami
- Negar Azarpira (ORCID: https://orcid.org/0000-0002-5549-0057)
- Fatemeh Ghaderi (ORCID: https://orcid.org/0009-0003-0117-1557)
- Reza Heidari (ORCID: https://orcid.org/0000-0002-7038-9838)
- Zahra Honarpishefard
- Kiana Yousefipour
- Nazi Dastkhosh
Institutions
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- Clinical and Experimental Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5114/ceh.2025.151865
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00