Comparative transcriptome profiling of the lumbosacral dorsal root ganglia reveals sexually dimorphic gene expression in a murine model of coronavirus-induced neurodegeneration

This study confirmed a differential expression of immune, inflammatory, and neural DEGs in sensory ganglia of male and female mice undergoing CNS neurodegeneration and neuroinflammation. The obtained results suggest a functional role of sex-dependent sensory interoception in the development of neurogenic LUTS in a coronavirus-induced murine model of MS.