Sulforaphane induces cell morphology change and cell apoptosis by activating endoplasmic reticulum stress in glioblastoma
This study demonstrates that SFN induces GBM cell apoptosis via activation of the UPR pathway, particularly through the ATF4-CHOP axis. These findings support the potential of SFN as a promising therapeutic agent for glioblastoma.
Authors
- A. Wang (ORCID: https://orcid.org/0009-0007-8282-7659)
- Tongcui Jiang (ORCID: https://orcid.org/0000-0002-6894-7490)
- Yan Jiang (ORCID: https://orcid.org/0000-0002-3524-2857)
- Chengyu Xia (ORCID: https://orcid.org/0000-0002-3703-9879)
- Huimin Dai (ORCID: https://orcid.org/0000-0001-8468-4072)
- Nan Li (ORCID: https://orcid.org/0000-0003-0471-6025)
- Tongchao Jiang (ORCID: https://orcid.org/0000-0002-9252-9301)
Institutions
- Northwestern University (US)
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12885-025-14378-4
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Medical University