Selection and evaluation of high molecular weight compounds for the development of a gel base

Introduction: gels, as a medicinal and cosmetic form, are widely used in medicine and cosmetology and consist of a gel base and a medicinal substance distributed in it, therefore development of a suitable gel base begins with the selection of high molecular weight compounds at the optimal concentration that impart the appropriate rheological properties to the desired dosage form. In this work, solutions of polymer gels (HPMC, carbopol and sodium alginate) of various concentrations were prepared to conduct tests and determine their properties. Purpose: the purpose of the study was to study the properties of high molecular weight compounds to use it for developing a gel bases. Material and methods: To achieve this goal, polymer gels of various concentrations were prepared and rheological and technological properties were studied: viscosity, shear resistance, spreadability, covering ability. Results: the results obtained showed that the studied polymer gels have the desired properties, such as unifed coverage on the skin area and the ability to return to its original viscosity after deformation. Conclusion: the study made it possible to identify promising gelling agents that can be used for the development of a gel preparations due to their high efficiency and ease of use