Problem of residual quantities rationing and development of modern methods for determination of herbicides in medicinal plant raw materials

Introduction. Medicinal plants, which are the basis of many medicines and a source of promising pharmaceutical substances, are at significant risk of contamination with various toxic substances in the modern man-made environment due to the increasing influence of anthropogenic factors on all parts of the natural environment. On the territory of the Russian Federation, the problem of the content of residual amounts of pesticides in medicinal plants and raw materials for the production of medicines and biologically active additives is still poorly understood. Due to insufficient regulation of the handling of pesticides, the risk of contamination remains significant. The purpose of this review is to study the regulatory framework for the permissible content of pesticides and methods for detecting a derivative of chlorobenzoic acid, the herbicide dicamba. Material and methods. The content analysis was carried out using legal and regulatory documentation regulating the quality of LRS in terms of herbicide content. In our country, the rules for handling them are regulated by the "State Catalog of pesticides and agrochemicals approved for use in the Russian Federation" and the requirements of the State Pharmacopoeia of the Russian Federation XV edition. The quality of medicinal plant raw materials imported from other countries must comply with the Uniform Sanitary, Epidemiological and Hygienic Requirements for goods subject to sanitary and epidemiological supervision (control). Results. Dicamba (3,6-dichloro-2-methoxybenzoic acid) can be classified as a group of herbicides with auxin-like activity. Using the example of the chlorine-containing aromatic herbicide dicamba, it has been shown that it is potentially dangerous to human health after ingestion, even in small quantities. It is shown that the issue of the content of residual amounts of pesticides in plant raw materials is insufficiently regulated on the territory of the Russian Federation. Conclusion. There are no modern selective and highly sensitive methods for determining the residual content of dicamba both in medicinal plants and in the soil at their cultivation sites.