A retrospective propensity-matched study comparing whole-brain radiotherapy with simultaneous integrated boost to whole-brain radiotherapy alone for brain metastases
WBRT-SIB is a promising strategy for patients with BM. Compared to WBRT alone, WBRT-SIB can significantly prolong the intracranial PFS (including local and distant PFS). Additionally, while WBRT-SIB did not improve OS in the entire cohort, the OS benefit for patients with BM accompanied by infratentorial involvement warrants further exploration.
Authors
- Zheqing Liu
- Yuanyuan Chen (ORCID: https://orcid.org/0000-0002-1611-0111)
- Xiaojing Du (ORCID: https://orcid.org/0000-0002-3610-1511)
- Shaoxiong Wu (ORCID: https://orcid.org/0000-0002-9388-6239)
- Meiling Deng
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12885-025-14443-y
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52