Diagnostic performance of EBV DNA load testing for nasopharyngeal carcinoma in nasopharyngeal swab outperforms the approach in other specimens
We demonstrated that EBV DNA load in NPS could better discriminate NPC patients from controls than the approach in plasma. EBV DNA load in saliva had no value for NPC diagnosis. The combination of EBV DNA load in NPS with EBV antibody could further improve the specificity, while maintaining a rather good sensitivity for NPC diagnosis.
Authors
- Zhicong Wu (ORCID: https://orcid.org/0000-0002-9408-4019)
- Kena Lin (ORCID: https://orcid.org/0000-0002-1769-8551)
- Wei‐Ting Lin (ORCID: https://orcid.org/0000-0001-5556-2754)
- Su‐Mei Cao (ORCID: https://orcid.org/0000-0003-1749-517X)
- J H Ye
- Ling Guo (ORCID: https://orcid.org/0000-0001-7133-3951)
- Yucong Cai
- Yifan Peng (ORCID: https://orcid.org/0000-0001-9309-8331)
- Xueqi Li (ORCID: https://orcid.org/0000-0001-5448-3819)
- Shang‐Hang Xie
- Hang-Ning Zhou
- Zheng Ma (ORCID: https://orcid.org/0000-0003-1683-4299)
- Dong‐Feng Lin
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- Key Laboratory of Guangdong Province (CN)
- Sun Yat-sen University Cancer Center (CN)
- Guangdong Provincial People's Hospital (CN)
- Beijing Center for Disease Prevention and Control (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12885-025-14539-5
- Citations
- 1
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation