Central Precocious Puberty: Case Report of a 6-Year-Old Girl

Background: Central precocious puberty (CPP) is a condition characterized by the early appearance of secondary puberty signs before the expected age, caused by premature activation of the hypothalamic-pituitary-gonadal axis. This condition can impact the child’s physical growth, psychosocial development, and long-term health, requiring a comprehensive diagnostic approach. Case: A 6-year-old girl presented with a lump in the left breast without pain or other signs of inflammation. Physical examination showed Tanner stage M2P1 puberty status. Laboratory results indicated LH levels of 0.31 mIU/mL, FSH 5.52 mIU/mL, and Estradiol 10.99 pg/mL. Radiological bone age assessment showed consistency with an age of 5 years and 9 months. The diagnosis of CPP was established based on anamnesis, physical examination, and hormonal profile, although bone age did not show significant advancement. The patient received intramuscular Medroxyprogesterone therapy. Conclusion: The diagnosis of CPP is not always accompanied by accelerated bone age. A comprehensive evaluation, including anamnesis, pubertal status, and hormonal profiling, remains the key to establishing the diagnosis. Early detection and intervention are important to prevent long-term impacts on the child’s growth and psychosocial development.