Electroacupuncture Attenuates High‐Fat Diet‐Exacerbated Alzheimer's Pathology by Enhancing <scp>TFEB</scp>/<scp>TFE3</scp>‐Mediated Autophagic Clearance of Tau and <scp>NLRP3</scp> Inflammasome in <scp>3xTg</scp> Mice
This study proposes EA-ST36 as a promising therapeutic strategy for counteracting HFD-induced AD pathology by activating TFEB/TFE3-driven autophagic pathways, thereby enhancing the clearance of toxic protein aggregates and inflammasome components. These findings advance our understanding of EA's molecular mechanisms in AD therapy, offering a novel, nonpharmacological approach for mitigating diet-induced exacerbation of neurodegenerative processes.
Authors
- Runjin Zhou
- Guozhi Huang (ORCID: https://orcid.org/0000-0002-5889-0603)
- Chuyu Deng
- Xiaoyan Zheng (ORCID: https://orcid.org/0000-0002-2740-7076)
- Chunzhi Tang (ORCID: https://orcid.org/0000-0003-3127-578X)
- Jihua Zou
- Dongmin Liu (ORCID: https://orcid.org/0000-0002-3877-8198)
- Zhihao Luo (ORCID: https://orcid.org/0000-0003-2246-4765)
- Ju‐Xian Song (ORCID: https://orcid.org/0000-0001-7266-2060)
- Jialin Zheng (ORCID: https://orcid.org/0000-0003-2286-0151)
- Yiming Chen (ORCID: https://orcid.org/0000-0002-9569-1929)
- Qing Zeng (ORCID: https://orcid.org/0000-0002-1206-7785)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Zhujiang Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/cns.70497
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangzhou Municipal Science and Technology Project