Genomic surveillance reveals geographical heterogeneity and differences in known and novel insecticide resistance mechanisms in Anopheles arabiensis across Kenya
Restricted gene flow coupled with heterogeneity in molecular insecticide resistance across Kenya suggests that localized control measures may be more effective in preventing the spread of insecticide resistance in An. arabiensis. This study highlights the importance of incorporating genomics in the routine monitoring of malaria vector populations to identify the emergence of new resistance signatures and their geographic distribution and spread.
Authors
- David Mburu (ORCID: https://orcid.org/0000-0003-1255-0678)
- Luna Kamau (ORCID: https://orcid.org/0000-0002-2186-0283)
- Elijah O. Juma
- Brian Polo (ORCID: https://orcid.org/0009-0002-7505-9050)
- Charles Mbogo (ORCID: https://orcid.org/0000-0001-5335-6551)
- Eric Ochomo (ORCID: https://orcid.org/0000-0002-4042-4970)
- Stanley Kitur
- Silas Agumba
- Kelly L. Bennett (ORCID: https://orcid.org/0000-0003-0330-5275)
- Joseph Mwangangi (ORCID: https://orcid.org/0000-0001-5437-4241)
- Chris S. Clarkson (ORCID: https://orcid.org/0000-0002-8757-1660)
- Lucy Wachira
- Alistair Miles (ORCID: https://orcid.org/0000-0001-9018-4680)
- Jon Haël Brenas (ORCID: https://orcid.org/0000-0001-9395-9365)
- Damaris Matoke-Muhia (ORCID: https://orcid.org/0000-0001-7737-8069)
- Edith Ramaita
- Sonia Barasa
Institutions
- Liverpool School of Tropical Medicine (GB)
- Pwani University (KE)
- Wellcome Sanger Institute (GB)
- Kenya Medical Research Institute (KE)
- Pan Africa Christian University (KE)
- Kenya Industrial Research and Development Institute (KE)
- Ministry of Health (KE)
- American Mosquito Control Association (US)
- Ministry of Health (BB)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12864-025-11788-3
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Bill and Melinda Gates Foundation
- Broad Institute
- European Commission
- Medical Research Council
- National Institute of Allergy and Infectious Diseases
- European and Developing Countries Clinical Trials Partnership