Mechanisms underlying the estradiol mediated protection of yak oviduct epithelial cells against ER-Ca2+ imbalance
Our research results indicate that E<sub>2</sub> protects YOECs under ER-Ca<sup>2+</sup> imbalance by increasing the protein expression of IP3R3 serine 927, highlighting the close relationship between protein expression and phosphorylation modification during ER-Ca<sup>2+</sup> imbalance. These findings deepen our understanding of ER-Ca<sup>2+</sup> imbalance damage and lay the foundation for further research and mitigation of related diseases.
Authors
- Yangyang Pan (ORCID: https://orcid.org/0000-0002-7617-8070)
- Sijiu Yu (ORCID: https://orcid.org/0000-0002-6252-6046)
- Rui Zhang (ORCID: https://orcid.org/0000-0003-3342-1621)
- Yan Cui (ORCID: https://orcid.org/0000-0002-2800-6039)
- Ling Zhao
- Tianhao Li (ORCID: https://orcid.org/0000-0001-5716-8320)
- Xiaolin Ye (ORCID: https://orcid.org/0000-0003-0086-0601)
- Jinglei Wang (ORCID: https://orcid.org/0000-0002-8877-1496)
- Meng Wang (ORCID: https://orcid.org/0000-0001-7648-9955)
Institutions
- Gansu Agricultural University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12864-025-11804-6
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China