Impurity Profiling and Mechanistic Investigation of the Photochemical Degradation of Tetrandrine
This study provides the first mechanistic atlas of tetrandrine's photodegradation, identifying three dominant pathways: oxidative skeletal modification, oxidative ring-opening, and radical-mediated C-N cleavage. This study establishes a robust framework for the impurity analysis of natural product-derived drugs and provides actionable guidelines for stabilizing tetrandrine during manufacturing and storage.
Authors
- Feng Wang
- Weiran Yang (ORCID: https://orcid.org/0000-0001-8053-7753)
- Jinlong Chen (ORCID: https://orcid.org/0000-0003-2238-719X)
- Ruihan Zheng (ORCID: https://orcid.org/0009-0001-7676-9022)
- Jinmei Tan
Institutions
- Nanchang University (CN)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/rcm.10102
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- National Key Research and Development Program of China