Heterogeneous protein dynamics links to mitochondrial activity, glucose transporter, and ALDH cancer stem cell properties
These data provide additional insights into the functional characteristics of proteasome-low/ALDH-high CSCs, indicating a metabolic phenotype of reduced reliance on aerobic glycolysis and a decreased protein synthesis rate. We also identify specific chaperone and ubiquitin ligase activities that can be used to identify CSCs, with corresponding implications for therapeutic strategies that target CSCs through their altered metabolic properties.
Authors
- Zuzana Tylichová (ORCID: https://orcid.org/0000-0003-0433-5505)
- Philip J. Coates (ORCID: https://orcid.org/0000-0003-1518-6306)
- Bořivoj Vojtěšek (ORCID: https://orcid.org/0000-0001-6194-3705)
- Petr Müller (ORCID: https://orcid.org/0000-0002-8404-4494)
- Martin Krkoška (ORCID: https://orcid.org/0000-0002-9306-9140)
- Pavlína Zatloukalová
Institutions
- Masaryk Memorial Cancer Institute (CZ)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12885-025-14460-x
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- European Commission
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Grantová Agentura České Republiky
- Ministerstvo Zdravotnictví Ceské Republiky