Shikonin inhibits epithelial-mesenchymal transition in glioblastoma cells by upregulating p53 and promoting miR-361-5p level to suppress ZEB1 expression
Shikonin suppresses glioma cell proliferation, migration, invasion, and EMT by inhibiting ZEB1 expression through the p53/miR-361-5p axis.
Authors
- Shiwen Xu (ORCID: https://orcid.org/0000-0002-3624-2410)
- Yixue Xue (ORCID: https://orcid.org/0000-0001-5578-2693)
- Fengying Zhang (ORCID: https://orcid.org/0000-0002-5087-3884)
- Zhiyi Liu (ORCID: https://orcid.org/0000-0003-0587-2652)
- Hao Liang (ORCID: https://orcid.org/0000-0002-5284-1720)
- Gang Li (ORCID: https://orcid.org/0000-0001-8063-7754)
- Lin Zuo (ORCID: https://orcid.org/0000-0001-5399-3825)
- Yingbin Wang
Institutions
- Central Hospital Affiliated to Shenyang Medical College (CN)
- Shenyang First People's Hospital (CN)
- China Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12868-025-00956-6
- Citations
- 2
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- Shenyang Science and Technology Bureau