Restricted mean survival time approach versus time-varying coefficient Cox model for quantifying treatment effect when hazards are non-proportional
Overall, Cox TVC is a viable option for summarising treatment effect using LER and LED under non-PH conditions. It would be beneficial to complement the reporting by providing estimates of HR at specific milestone to detect early differences.
Authors
- Yu Yang Soon (ORCID: https://orcid.org/0000-0002-1995-2170)
- Tianyuan Gu (ORCID: https://orcid.org/0000-0002-9287-2206)
- Joseph Wee (ORCID: https://orcid.org/0000-0002-7410-6153)
- Zhaojin Chen (ORCID: https://orcid.org/0000-0002-3770-2781)
- Bee‐Choo Tai
Institutions
- National University of Singapore (SG)
- National University Cancer Institute, Singapore (SG)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
- National University Health System (SG)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12874-025-02608-z
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National University Health System