Prognostic model of lung adenocarcinoma based on disulfidptosis-related genes and analysis of in vitro cell experiments for PPP1R14B in the model
The risk model constructed based on four DRGs can predict the prognosis of LUAD patients with relative accuracy. There are differences in the immune microenvironment between the high-risk and low-risk groups. Patients in the high-risk group are more sensitive to drugs such as gefitinib, afatinib, lapatinib, and paclitaxel, providing a reference for personalized treatment of LUAD patients. Knockdown PPP1R14B significantly inhibited the proliferation and migration of LUAD cells and promoted the apoptosis of LUAD cells.
Authors
- Ying Zhang (ORCID: https://orcid.org/0000-0001-6320-8253)
- Shuyang Xie (ORCID: https://orcid.org/0000-0002-8090-2180)
- Haoran Liu (ORCID: https://orcid.org/0000-0003-2226-4974)
- Pingyu Wang (ORCID: https://orcid.org/0000-0003-0980-4294)
- Xintong Jiang (ORCID: https://orcid.org/0000-0003-2082-6048)
- Yuqing Dong (ORCID: https://orcid.org/0000-0003-3127-2204)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Yantai University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13062-025-00662-7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province