A prospective diagnostic study investigating urinary biomarkers of AKI in major abdominal surgery (the AKI-biomas study)
In this large prospective study of a clinical cohort of 488 patients undergoing major abdominal surgery AKI rates are dependent on the criteria used with 49.5% of patients developed AKI by urine output criteria, compared to only 8.8% by serum creatinine. NGAL and IGFBP-7*TIMP-2 showed reasonable diagnostic performance when diagnosing AKI by serum creatinine criteria, with NGAL returning the highest AUC values.
Authors
- Rishabh Singh
- Lui G. Forni (ORCID: https://orcid.org/0000-0002-0617-5309)
- Timothy Rockall (ORCID: https://orcid.org/0000-0001-8488-7005)
- T. N. Singh (ORCID: https://orcid.org/0000-0002-0324-7821)
- William C. MacLean (ORCID: https://orcid.org/0000-0002-0336-6839)
- Paul Mackenzie
Institutions
- Royal Surrey County Hospital (GB)
- Royal Surrey NHS Foundation Trust (GB)
Publication Details
- Journal
- Critical Care
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13054-025-05510-8
- Citations
- 3
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- Royal College of Surgeons of England
- University of Surrey