Association of magnetic resonance imaging glymphatic function with gray matter volume loss and cognitive impairment in Alzheimer’s disease: a diffusion tensor image analysis along the perivascular space (DTI-ALPS) study
There is a significant relationship between the DTI-ALPS index, cortical metrics, and cognitive function. This result may suggest that lymphatic dysfunction indicated by the DTI-ALPS index could mirror cortical structural degeneration and cognitive decline within the pathological process of AD. DTI-ALPS can be used as an indicator of structural degeneration and decline in cognitive function in AD.
Authors
- Xiaolong Liang (ORCID: https://orcid.org/0000-0003-1238-6126)
- Yuqi Zhi
- Qian Zhang (ORCID: https://orcid.org/0000-0001-6274-1494)
- Ting Huang (ORCID: https://orcid.org/0000-0001-7540-274X)
- Shanwen Liu
- Zhen Jiang (ORCID: https://orcid.org/0000-0002-0616-5514)
- Jing Zhu (ORCID: https://orcid.org/0000-0002-2175-9476)
- Meng Li (ORCID: https://orcid.org/0000-0002-8320-5241)
- Hua Hu
- Rong Liu (ORCID: https://orcid.org/0000-0001-7477-6520)
- Chaogang Wei
- Chong Cui
Institutions
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Neusoft (China) (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2025-07-01
- DOI
- https://doi.org/10.21037/qims-2025-96
- Citations
- 3
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 2.73