Abnormal topological properties and functional-structural coupling of large-scale brain networks in primary angle-closure glaucoma
We observed significantly weaker FC-SC coupling in patients with PACG compared to HCs, indicating impaired integration of brain structure and function. This decoupling suggests widespread network-level disruption, and this finding advances our understanding of optic nerve damage and cognitive deficits in PACG.
Authors
- Min Yan (ORCID: https://orcid.org/0000-0002-5515-5865)
- Chan Xiong (ORCID: https://orcid.org/0000-0002-9975-945X)
- Zhijun Luo (ORCID: https://orcid.org/0009-0007-7901-7591)
- Jian Li (ORCID: https://orcid.org/0000-0002-4549-0694)
- Shenghong Li (ORCID: https://orcid.org/0000-0002-0767-2307)
- Bo Wang (ORCID: https://orcid.org/0000-0003-3688-6328)
- Jialu Chen (ORCID: https://orcid.org/0000-0002-6633-8181)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0002-6666-0090)
- Xianjun Zeng
Institutions
- Nanchang University (CN)
- Jiangxi Provincial Academy of Medical Sciences (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2025-07-01
- DOI
- https://doi.org/10.21037/qims-24-1947
- Citations
- 2
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.41