Altered coupling of cerebral blood perfusion and neuronal activity in children with MRI-negative drug refractory epilepsy
The study reveals the cerebral blood perfusion, neuronal activity, global and regional NVC alteration in children with magnetic resonance imaging (MRI)-negative DRFE non-invasively, associated with lower cognitive performance. These findings indicate that NVC-based study can better integrate information of neuronal activity and cerebral hemodynamics, offering a new insight into the neuropathological mechanisms of DRFE and providing potential imaging biomarkers, and neurovascular decoupling may help clinical classification for childhood DRFE.
Authors
- Guiqin Chen (ORCID: https://orcid.org/0000-0002-2820-1344)
- Yuxin Xie (ORCID: https://orcid.org/0000-0001-5431-365X)
- Yulun He
- Haifeng Ran
- Jie Hu (ORCID: https://orcid.org/0000-0003-3210-5889)
- Qiane Yu
- Tijiang Zhang (ORCID: https://orcid.org/0000-0002-5517-9226)
- Xuhong Li (ORCID: https://orcid.org/0000-0002-9293-0904)
- Kexin Huang (ORCID: https://orcid.org/0009-0001-5697-6710)
Institutions
- Union Hospital (HK)
- Zunyi Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2025-07-01
- DOI
- https://doi.org/10.21037/qims-2024-2756
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00