Clinical characteristics and efficacy of CP/CPPS IIIa treatment in patients with abdominal obesity

Background: obesity is defined as excessive accumulation of adipose tissue in the body, adversely affecting health. Given the established pathogenic correlations between abdominal obesity (AO) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), investigation of the AO impact on the CP/CPPS manifestations represents a relevant focus in contemporary uroandrology Aim: to identify the clinical patterns, laboratory and instrumental findings, and to evaluate the efficacy of therapeutic approaches in young patients with CP/CPPS IIIa and concomitant AO Materials and Methods: between 2018 and 2022, a comprehensive urological examination was performed on 150 young men (aged 18–44 years) diagnosed with CP/CPPS IIIa. The assessment included validated questionnaires (NIH-CPSI, SFM) Treatment efficacy was analyzed in patient groups stratified by the presence of AO (waist circumference ≥94 cm). Results: in patients with AO, the clinical profile of CP/CPPS IIIa, as determined by the NIH-CPSI, was characterized by more pronounced pain and voiding symptoms, as well as lower disease-specific quality of life scores. SFM domains evaluating libido, erectile function, ejaculation, sexual satisfaction, and overall psychological assessment of sexual activity were significantly lower in the AO group. Hormonal imbalance, mainly due to elevated estriol levels, was observed in patients with AO. Considering the greater severity of symptoms in the AO group, a prostate extract preparation was added to the standard therapeutic regimen. By week 4, a significant reduction in CP/CPPS symptoms was noted in both groups Conclusion: the most severe clinical manifestations of CP/CPPS were found in men with AO Active identification and timely management of AO by interdisciplinary specialists are necessary for the prevention of male reproductive system disorders The use of a prostate extract preparation as part of combination therapy for CP/CPPS in men with AO has shown effectiveness KEYWORDS: chronic prostatitis, pelvic pain, abdominal obesity, somatometry. FOR CITATION: Vinnik Yu.Yu., Amelchenko A.A. Clinical characteristics and efficacy of CP/CPPS IIIa treatment in patients with abdominal obesity. Russian Medical Inquiry. 2025;9(4):223–228 (in Russ.). DOI: 10.32364/2587-6821-2025-9-4-6