Evaluation of Metastatic Insulinoma With Severe Hypoglycemia Using 68Ga-Exendin-4 PET/CT
A 52-year-old man was pathologically diagnosed with a pancreatic neuroendocrine tumor (pNET) and synchronous liver metastasis through debulking surgery 2 years ago. Recently, the patient showed recurrent severe hypoglycemia after receiving multiple treatments. 68 Ga-Exendin-4 PET/CT imaging revealed diffuse uptake in the skeleton and other metastatic sites, which 68 Ga-DOTANOC PET/CT grossly underestimated. This case highlights the crucial role of 68 Ga-Exendin-4 in the comprehensive and accurate evaluation of metastatic insulinomas.
Authors
- Shaoli Song (ORCID: https://orcid.org/0000-0003-2544-7522)
- Jie Chen (ORCID: https://orcid.org/0000-0001-8113-3515)
- Yun Liang (ORCID: https://orcid.org/0000-0002-0364-6195)
- Jing Gao (ORCID: https://orcid.org/0000-0002-3613-9413)
- Junyan Xu (ORCID: https://orcid.org/0009-0008-3582-847X)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Laboratoire d’Imagerie Biomédicale (FR)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1097/rlu.0000000000006008
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00