Identification of candidate proteins influencing spermatogenesis in Shandong black cattle via integrated multiomics analysis
A combined analysis revealed that UDPG upregulation enhances MCM3/MCM4 activity during S phase, thereby promoting spermatogenesis. Hypoxanthine upregulation inhibits the activity of CDK1, leading to a blockage in the transition from the G2/M phase of the cell cycle, thereby inhibiting spermatogenesis. In summary, MCM3, MCM4, and CDK1 participate in regulating the process of testis spermatogenesis.
Authors
- Yanfang Mei
- Lei Zou (ORCID: https://orcid.org/0000-0002-8586-4400)
- Renzheng Zhang (ORCID: https://orcid.org/0000-0002-3729-4220)
- Ruili Liu (ORCID: https://orcid.org/0000-0002-7518-7530)
- Jiaxu Ma
- Xiuyuan Wang (ORCID: https://orcid.org/0009-0002-3404-1022)
- Yajuan Dong (ORCID: https://orcid.org/0000-0002-0911-4755)
- Qiuyue Zhao
- Xiuping Miao
- Xuejin Bai
Institutions
- Shandong University of Technology (CN)
- Qingdao Agricultural University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12864-025-11825-1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00