A constricted mitochondrial morphology formed during respiration
Mitochondria assemble in a dynamic tubular network. Their morphology is governed by mitochondrial fusion and fission, which regulate most mitochondrial functions including oxidative phosphorylation. Yet, the link between mitochondrial morphology and respiratgion remains unclear. Here, we uncover a mitochondrial morphology dedicated to respiratory growth of Saccharomyces cerevisiae, which we refer to as "Ringo". The Ringo morphology is characterized by stable constrictions of mitochondrial tubules. Ringo constrictions are mediated by the yeast dynamin Dnm1 and, unlike mitochondrial fission, occur in the absence of contacts with the endoplasmic reticulum. Our data show that blocking formation of the Ringo morphology correlates with decreased respiration, decreased expression of OXPHOS subunits and perturbed mitochondrial DNA distribution. These results open important perspectives about the link between mitochondrial form and function.
Authors
- Perrine Bomme (ORCID: https://orcid.org/0000-0002-4724-4382)
- Adeline Mallet (ORCID: https://orcid.org/0000-0003-1604-7308)
- Cynthia Alsayyah (ORCID: https://orcid.org/0000-0003-1714-031X)
- Mickaël Lelek (ORCID: https://orcid.org/0000-0003-4881-3847)
- Aurélia Barascu (ORCID: https://orcid.org/0000-0001-5961-8794)
- Christina Kunz (ORCID: https://orcid.org/0009-0001-9483-2355)
- Manish Kumar Singh (ORCID: https://orcid.org/0000-0002-0863-3238)
- Maria Teresa Teixeira (ORCID: https://orcid.org/0000-0002-9466-7951)
- Naïma Belgareh‐Touzé
- Mickaël M. Cohen (ORCID: https://orcid.org/0000-0002-1372-680X)
- Laetitia Cavellini (ORCID: https://orcid.org/0000-0003-1743-2689)
- Christophe Zimmer (ORCID: https://orcid.org/0000-0001-9910-1589)
- Maria Angeles Morcillo-Parra
- Lea Dietrich (ORCID: https://orcid.org/0000-0002-9661-4554)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- University of Würzburg (DE)
- Sorbonne Université (FR)
- Institut de Biologie Physico-Chimique (FR)
- Max Planck Institute of Biophysics (DE)
- Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes (FR)
- Saarland University (DE)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1038/s41467-025-60658-9
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- European Commission
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Max-Planck-Gesellschaft
- Institut National Du Cancer
- National Cancer Institute