METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression
METTL3 promotes MCL progression through YTHDF2-mediated degradation of Ambra1 mRNA, suggesting that the METTL3/YTHDF2/Ambra1 may serve as a potential therapeutic target for MCL.
Authors
- Zhiping Jiang (ORCID: https://orcid.org/0000-0003-4742-6538)
- Tao Duan (ORCID: https://orcid.org/0000-0001-5320-4611)
- Shujun Li (ORCID: https://orcid.org/0000-0001-5959-3160)
- Simin Deng (ORCID: https://orcid.org/0009-0000-0663-7078)
- Wenjia Wei (ORCID: https://orcid.org/0009-0007-3693-5069)
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12967-025-06647-4
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Hunan Province