Hodgkin Lymphoma in the Republic of Mordovia (2013–2023): Incidence, Mortality, Regional Disparities vs National Trends

Introduction. Hodgkin lymphoma (HL) is a malignant neoplasm of the lymphatic system, necessitating investigation into its regional epidemiology and pathohistological characteristics. The aim of the study is to identify the trends in HL incidence and mortality in the Republic of Mordovia for 2013–2023 and to compare these data with nationwide figures for the Russian Federation.Materials and Methods. Research data were obtained from the medical statistics registries of the Republic of Mordovia and the Russian Federation for the period of 2013–2023, supplemented by publications on HL epidemiology and pathology. Age-standardized incidence and mortality rates were calculated using the direct standardization method (European Standard Population 2013, ESP-2013). Inter-group differences were assessed using one-way and multifactorial analysis of variance (ANOVA; α = 0,05).Results. The study demonstrated a regional incidence rate exceeding the national average by 65 %. Furthermore, incidence among females was 29 % higher than among males. A significant decline in mortality was observed (43,3 % in males, 19,6 % in females). By 2023, this reduction surpassed the national average by 45 percentagepoints (pp) for males and 76 pp for females.Discussion and Conclusion. The significant decline in mortality rates indicates the effectiveness of diagnostic and therapeutic interventions within the region. However, the persistently high incidence rate, particularly among females, translates into a continued elevated risk of HL mortality in the Republic of Mordovia compared to national levels. These data provide a foundation for further oncological and hematological research in the region and necessitate ongoing epidemiological surveillance focused on addressing the identified disparities.