RNA binding protein HuR regulated by OIP5-AS1 may be involved in maternal transcript degradation during the human maternal-to-zygotic transition
The HuR protein plays a critical role in influencing the degradation of maternal transcripts during the MZT in early human embryonic development. Understanding the role of OIP5-AS1 in regulating HuR protein could provide valuable insights into developmental biology and potentially lead to new therapeutic strategies for developmental disorders.
Authors
- Yanna Liu (ORCID: https://orcid.org/0000-0002-6573-4318)
- Jingbin Yan (ORCID: https://orcid.org/0000-0003-3398-2322)
- Jiajun Qiu (ORCID: https://orcid.org/0000-0003-1790-8536)
- Wei Hao (ORCID: https://orcid.org/0000-0001-5542-7608)
- Yuehua Zhang (ORCID: https://orcid.org/0000-0003-1432-5423)
- Fanyi Zeng (ORCID: https://orcid.org/0000-0003-0955-5099)
- Wenxiu Li (ORCID: https://orcid.org/0000-0003-3530-6619)
- Keyi Li
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12864-025-11807-3
- Citations
- 2
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China