doc2a and doc2b contribute to locomotor and social behaviors by down-regulating npas4b in zebrafish
This study suggests that DOC2A in the critical region of 16p11.2 may contribute to the pathogenesis of autism by interacting with other genes, such as DOC2B, and that the downregulation of NPAS4 may play an important role in autism.
Authors
- Xinping Yang (ORCID: https://orcid.org/0000-0003-4086-4180)
- Wanshan Wang (ORCID: https://orcid.org/0009-0007-1569-1421)
- Zezhen Du
- Yali Chi (ORCID: https://orcid.org/0000-0002-9325-3271)
- Wenjun Yu (ORCID: https://orcid.org/0009-0007-4887-6879)
- Haihua Liu (ORCID: https://orcid.org/0000-0003-4075-511X)
- Tao Feng
- Ping Huang (ORCID: https://orcid.org/0009-0000-8767-0776)
Institutions
- Guangzhou University (CN)
- Ministry of Education (RW)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12915-025-02224-9
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province